Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mtor  mechanistic target of rapamycin kinase   (Synonyms: 2610315D21Rik, FKBP-rapamycin-associated protein FRAP, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase), RAFT1, RAPT1)
Results	Reference
1*	J:130984 Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I, A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):270-5
1	J:334838 Chang JH, Chou CH, Wu JC, Liao KM, Luo WJ, Hsu WL, Chen XR, Yu SL, Pan SH, Yang PC, Su KY, LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway. Commun Biol. 2023 Apr 10;6(1):389
1	J:272052 Cheng X, Ma X, Zhu Q, Song D, Ding X, Li L, Jiang X, Wang X, Tian R, Su H, Shen Z, Chen S, Liu T, Gong W, Liu W, Sun Q, Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol Cell. 2019 Feb 21;73(4):788-802.e7
1	J:266104 Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW, mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502
1	J:281393 Chung C, Ha S, Kang H, Lee J, Um SM, Yan H, Yoo YE, Yoo T, Jung H, Lee D, Lee E, Lee S, Kim J, Kim R, Kwon Y, Kim W, Kim H, Duffney L, Kim D, Mah W, Won H, Mo S, Kim JY, Lim CS, Kaang BK, Boeckers TM, Chung Y, Kim H, Jiang YH, Kim E, Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2(-/-) Mice. Biol Psychiatry. 2019 Apr 1;85(7):534-543
1	J:228212 Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C, FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5
1	J:246667 Cortez-Toledo O, Schnair C, Sangngern P, Metzger D, Chao LC, Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. PLoS One. 2017;12(2):e0171268
1	J:326089 Ghnaimawi S, Zhang S, Baum JI, Huang Y, The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
1*	J:154667 Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM, Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7
1	J:235665 He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A, Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016 Jun 1;143(11):1937-47
1*	J:153715 Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ, Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009 Oct;136(19):3347-56
1	J:249035 Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz PF, Tilly P, Roos M, McGillewie L, Bar S, Minocha S, Chevalier C, Po C, Chelly J, Mandel JL, Borgatti R, Piton A, Kinnear C, Loos B, Adams DJ, Herault Y, Collins SC, Friant S, Godin JD, Yalcin B, WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317
1	J:336227 Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R, Redowicz MJ, Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166748
1	J:211789 Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A, Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39
1	J:332423 Kong X, Shu X, Wang J, Liu D, Ni Y, Zhao W, Wang L, Gao Z, Chen J, Yang B, Guo X, Wang Z, Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development. Development. 2022 Dec 15;149(24):dev201286
1*	J:170203 Lague MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D, Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E936-46
1	J:154054 Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R, Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature. 2009 Oct 15;461(7266):1002-6
1	J:224980 Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR, Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054
1	J:232444 Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z, Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41
1*	J:238260 Liu TY, Chen YC, Jong YJ, Tsai HJ, Lee CC, Chang YS, Chang JG, Chang YF, Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Open Biol. 2017 Jan;7(1)
1	J:333829 Lopez-Tello J, Sferruzzi-Perri AN, Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Front Endocrinol (Lausanne). 2023;14:1116770
1	J:177840 Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, Pala M, Bulfone A, Garcia-Verdugo JM, Leocani L, Minicucci F, Poliani PL, Galli R, Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions. Cell Stem Cell. 2011 Nov 4;9(5):447-62
1	J:201333 Magri L, Cominelli M, Cambiaghi M, Cursi M, Leocani L, Minicucci F, Poliani PL, Galli R, Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models. Dis Model Mech. 2013 Sep-Oct;6(5):1185-97
1	J:171254 Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI, Fbxw7-dependent Degradation of Notch Is Required for Control of 'Stemness' and Neuronal-Glial Differentiation in Neural Stem Cells. J Biol Chem. 2011 Apr 15;286(15):13754-64
1	J:303303 Pan M, Yin Y, Wang X, Wang Q, Zhang L, Hu H, Wang C, Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. Autophagy. 2020 Aug 2;:1-16
1	J:311917 Qiu X, Wei R, Li Y, Zhu Q, Xiong C, Chen Y, Zhang Y, Lu K, He F, Zhang L, NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget. 2016 May 24;7(21):31440-53
1	J:269511 Roy A, Skibo J, Kalume F, Ni J, Rankin S, Lu Y, Dobyns WB, Mills GB, Zhao JJ, Baker SJ, Millen KJ, Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy. Elife. 2015 Dec 3;4:e12703
1	J:241448 Shin JY, Mendez-Lopez I, Hong M, Wang Y, Tanji K, Wu W, Shugol L, Krauss RS, Dauer WT, Worman HJ, Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth. Hum Mol Genet. 2017 Jan 01;26(1):65-78
1	J:121697 Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA, Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31
1	J:306367 Wei R, Qiu X, Wang S, Li Y, Wang Y, Lu K, Fu Y, Xing G, He F, Zhang L, NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Cell Signal. 2015 Mar;27(3):578-86
1*	J:187480 Westendorp B, Major JL, Nader M, Salih M, Leenen FH, Tuana BS, The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012 Jun;26(6):2569-79
1	J:326953 Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM 2nd, Sulzer D, Goldman JE, Tang G, Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex. Cell Rep. 2022 Jul 19;40(3):111085
1	J:151770 Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M, Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia. 2009 Oct;52(10):2130-41
1*	J:304555 Zamfirescu RC, Day ML, Morris MB, mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition. Am J Physiol Cell Physiol. 2021 Jan 1;320(1):C30-C44
1	J:306153 Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B, A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165988
1	J:195854 Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED, Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One. 2013;8(1):e54221